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 Department of  Pharmaceutics
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Research and Publication

 


Research In Pharmaceutics Covers A Broad Spectrum Of Pharmaceutical Sciences Ranging From The Design, Optimization, Formulation And Evaluation Of Drugs, Through Studies On Methods Of Various Drug Delivery Systems And On The Fate Of Drugs In Animals, To Research On The Clinical And Sociological Aspects Of Pharmacy.

  • To Build And Increase The Research Base And Capacity By Providing Research Support To  Postdoctoral Fellows And Graduate Students At The Participating Institutions In Newer Techniques

  • To Enhance Science And Technology Knowledge To The Staff And Students In Current Trends

  • The Faculty Of College Of Pharmacy  Is Actively Involving In Collaboration Program With Various Premier Institutions /Universities In India


Research Program Carried Out In The Following Area

  • Preformulation And Incompatibility Studies.

  • Formulation And Evaluation Of Controlled Drug Delivery System

  • Process Validation Of Formulated Products

  • Formulation And Evaluation Of Novel Drug Delivery System

  • Design, Optimization And Characterization Of Nanoparticles


Future Plans Of The Department

  • Targeted Drug Delivery System

  • Herbal Formulation And Standardization

  • Bioavailability And Bioequivalence Studies

  • Pharmacokinetic And Pharmacodynamic Models


Research Conducted

Ongoing Research Projects

  • Formulation Development And Evaluation Of Gastroretentive Floating Tablets Of Ranitidine Hydrochloride.

  • Design And Development Of Pulsincap Drug Delivery System As Drug Targeting Of Anti Hypertensive Drugs.

  • Formulation Development And Evaluation Of Dual Release Technology In The Form Of Inlay- Tablets Of Metformin Hydrochloride And Glibenclamide. 

  • Design, Development And Evaluation Of Chewable Soft Gelatin – Encapsulated Pharmaceutical Adsorbates.


For the year 2008-09

  •  Licensing And Technology Transfer From Research And Development To Production In Pharma Industry.

  • Formulation Development And Evaluation Of Mouth Dissolving Tablets Of Voglibose By Dried Compression Techniques

  • Formulation Development And Evaluation Of Losartan Potassium Immediate Release Tablets

  • Formulation And Evaluation Of Isosorbide Dinitrate Extended Release Matrix Tablets

  • Optimization And Evaluation Of Pioglitazone Coated Surface Modified PLGA Nanoparticles

  • Preparation, Characterization And Toxicity Study Of Polymeric Nanoparticles For Anti-Diabetic Drug – Repaglinide


For the year 2007-08

  • Formulation And Evaluation Of Non Aqueous Gel And Emulgel Containing Aceclofenac, Methyl  Salicylate , Menthol & Linseed Oil.

  • Formulation Development And Evaluation Of Amisulpride Oro Dispersible Tablets Prepared By   Effervescent  Technology.

  • Formulation Design And Evaluation Of Chewable Tablets Of Montelukast Sodium For Use In  Pediatrics.

  • Formulation Development  And  Evaluation Of Compression Coated Tablets Of Tamsulosin  Hydrochloride And Dutasteride.

  • Formulation,Evaluation And Invitro Release Kinectics Of Bilayer Tablets Containing Cefixime – Lactic Acid Bacillus And Dicloxacillin.


For the year 2006 -07

  • Formulation And Evaluation Of Ropinirole Hydrochloride Tablets.

  • Evaluation Of Porous Polypropylene Powder As A Carrier In The Development Of Floating Multiparticulate Unit System For Cardiovascular Drugs.

  • Formulation And Evaluation Of Aspirin/ Dypiridamole Tablets For Synergistic Antiplatelet Activity.

  • Formulation Development Of Olanzapine Orally Disintegrating Tablets.

  • Process Validation In Pharmaceutical Manufacturing.


Ongoing Ph.D. Projects

  • Bioadhesive Powder For Nasal Delivery Of Drugs (Progesterone).

  • Development And Evaluation Of Controlled Release Formulation For Inflammatory Diseases.

  • Studies Of Lactulose Formulations For Colon Specific Drug Delivery.

  • Study On Antiviral/Anticancer Activity Of Drugs Using Solid Lipid Nanoparticles.

  • Pharmacokinetic Studies On Flavonoids

  • Pharmacognostical, Phytochemical And Pharmacological Evaluation Of Incarvillea Species.

  • Study On Development And Evaluation Of Osmotically Controlled Oral Drug Delivery System For Inflammatory Drugs.

  • Formulation And Evaluation Of Sustained Ocular Delivery System.

  • Formulation And Evaluation Of Antimicrobial And Antileucorrhoea Tablets Of Herbal Origin.

  • Formulation And Evaluation Of Nanoparticles Entrapping Antituberculosis Drug.

  • Design Optimization And Characterization Of Antirheumatic Drug Loaded Nanoparticles.


Publications

International Journals

  • International Journal of Pharmacology and Biological Sciences, 2(1), 45-52, 2008. In vitro- In vivo Evaluation of a-Tocoferol and 5 – Fluorouracil liposomes in dalton’s ascitic lymphoma induced mice, N. Narayanan.
  • International Journal of Pharmaceutical science and Technology, ‘Formulation Design and Evaluation of Chewable Tablets of Montelukast sodium for Pediatric use’. - Paper accepted on 4.11.2008, N. Narayanan.
  • International Journal of Pharmacology, 3 (2), 175 – 178, 2007. Effect of a Polyherbal formulation (Diarun Plus) on the glycemic status modified by physiological means in non-diabetic mice and rats, N. Narayanan.
  • Oriental Pharmacy and Experimental Medicine, 7(2), 128-132, 2007. Effect of a polyherbal formulation (Diarun)  in experimental animals, N. Narayanan.
  • International Journal of Chemical Sciences, 5(5),  2034-2040, 2007. Formulation and Evaluation of Gelatin /Carbopal Microspheres containing Ibuprofen, N. Narayanan.
  • International Journal of Pharmaceutical Exipients, Apr-June 2006, 46 – 48.Effect of selected binders on the dissolution rate of Nimeuslide Tablets, N. Narayanan and S. Daisy Chellakumari.
  • International Journal of Tropical Medicine,  107 to 110, 2004. Evaluation of a herbal formulation on Streptozotocin induced diabetes in rats, N. Narayanan.
  • Pharmaceutical Biology (USA), vol. 40, No. 5,  362 – 368, 2002. Pharmacognostical studies on the roots of Clerodendron serratum, N. Narayanan.
  • Fitoterapia (Italy), 71,  147 – 153, 2000.Antipyretic, antinociceptive and anti-inflammatory activity of Premna herbacea roots, N. Narayanan.
  • Journal of Ethnopharmacology (USA), 65,  237 – 247, 1999 Antinociceptive, anti-inflammatory and antipyretic effects of ethanol extract of Clerodendron serratum roots in experimental animals, N. Narayanan.
  • American Asssociation of Pharmaceutical Sciencists Carbopol – Based Gels for Nasal Delivery of Progesterone, N. Narayanan.
  • International Journal of Pharmaceutical Sciences, Nigeria, (Paper accepted) Formulation and Characterization study of Novel Gastroretentive Multiparticulate Unit System, N. Narayanan.
  • International Journal Chemistry Science, 7 (1),2009, 523-532, Once Daily Fast Mouth Dissolving Tablets of Cetrizine Hydrochloride – Formulation and In vitro Evaluation, S. Sarojini, N. Narayanan, E. Suresh, M. Padmini, R. Loganathan and S. Sandhya.

National Journals

  • Holistic Mediscan, vol. 24, 7-9, June 2008. ‘Allopathy’ A Constituent Partner of Holistic System, N. Narayanan.

  • The Pharma Review, 32 – 39, (6), Feb. 2008, ‘Soft Gelatin Capsules - A Review’,  R.Devi Damayanthi and N. Narayanan. 

  • Pharma Buzz, 26 – 29, Dec. 2007, Design and Evaluation of Mucuadhesive buccal patches of Ketorolac Tromethamine, S. Daisy Chellakumari. and N. Narayanan.

  • The Indian Pharmacist, Aug 2007,p 87 – 88.Formulation and Evaluation of Tetracycline Hydrochloride Ophthalmic Inserts, S. Daisy Chellakumari. and S. Rajeswari

  • The Pharma Review, 137 – 138, Dec. 2004. A cost effective substitute for Cellusose acetate phthalate, N. Narayanan.

  • Indian Journal of Pharmaceutical Sciences, p: 453 – 454, July-Aug 2004 Comparative Antibacterial activities of Clerodendron serratum and Premna herbacea roots,N. Narayanan.

  • Pharma Blaze, p 18-19, Nov. 2000. Pharmacist – The elite job of USA, N. Narayanan.

  • Indian Journal of Gastroenterology, 3, p: 21, Nov. 1984, Anti-ulcer activity of Aloe indica, N. Narayanan.

  • Indian Journal of Natural products, Antibacterial and antifungal activity of fractions of the leaves of Plumeria alba Linn. R.Radha, T.Latha, N.Narayanan. Accepted. 2008.

  • Journal of Natural Remedies, 2004, vol. 4/2, 190 -194, Antibacterial and antifungal activities of ethyl acetate extract and the isolated fraction of Acanthospermum hisperidum DC, N. Deepa, N.N. Rajendran.

  • Journal of Natural Remedies, 2003, vol. 3/2, 208 -211, Antimicrobial activity of crude extracts of Heliotropium marifolium Retz,R. Radha, T. Latha and N.N. Rajendran.

  • Indian Drugs, Feb 2003, 40, 96-98, Antinociceptive effect of the extract of Cyphostemma setosum (Roxb) Alston as tested by formalin assay, G. Nartunai, P.M.K. Reddy, N.N. Rajendran.

  • Indian Jounal Exp. Biol., Oct 2001,39, 1009 – 1016, Modulation by insulin rather than blood glucose of the pain threshold in acute physiological and flavone induced antinociception in mice, N.N. Rajendran, P. Thirugnanasambandam, S. Parvathavarthini, S. Viswananthan, S. Ramaswamy.

  • Indian Journal Expt. Biol., Feb 2000, 38, 182 – 185, Antinociceptive pattern of flavone and its mechanism as tested by formalin assay, N. N. Rajendran, P. THirugnanasambandam, S.Viswanathan, S. Parvathavarthini, S. Ramaswamy.

  • Indian Drugs. (Paper communicated) Review of the chemistry and Biological studies on the genes Clerodendron Linn. .
  • Pharmatimes. (Paper communicated)  Preparation and In vitro controlled release characteristic of Salbutamol microcapsules
  • The Indian Pharmacist (Paper communicated)  Intra-nasal Bioavailability of Progestserone from Carbopol based gels
  • The Pharma- Review. (Paper communicated)  Spectrophotometric Analysis of Nimesulide Tablets
  • Indian Journal of Pharmaceutical Education and Research (Paper communicated)  Screening of soil samples of Coimbatore for Amylase producing organism
  • Indian Drugs (Paper communicated)  Simultaneous spectrophotometric Determination of  Chorphenaramine, Guaiphenecin and  Bromhexine from combined dosage forms
  • Indian Journal Pharmaceutical Sciences, (Paper communicated)   ‘Toxicological Studies of Progesterone Nasal Gels on Rabbit Mucosa and Slug Mucosa’
  • Journal of Pharmacology. (Paper communicated) Transdermal Drug Delivery System of Diltiazem Hydrochloride.
  • AAPS. (Paper communicated)Toxicological Studies of Progesterone Nasal Gels on Rabbit Nasal Mucosa and Slug Mucosa.
  • Antibacterial and antifungal activity of fractions of the leaves of Plumeria alba Linn. R.Radha, T.Latha, N.Narayanan. Accepted. Indian J of Nat. products. 2008.